abstract：:Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...

journal_title：Cell metabolism

authors： Li P,Ruan X,Yang L,Kiesewetter K,Zhao Y,Luo H,Chen Y,Gucek M,Zhu J,Cao H

更新日期：2015-03-03 00:00:00

abstract：:Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of m...

journal_title：Cell metabolism

authors： He L,Wondisford FE

更新日期：2015-02-03 00:00:00

abstract：:Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human...

journal_title：Cell metabolism

authors： Loh NY,Neville MJ,Marinou K,Hardcastle SA,Fielding BA,Duncan EL,McCarthy MI,Tobias JH,Gregson CL,Karpe F,Christodoulides C

更新日期：2015-02-03 00:00:00

abstract：:C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ...

journal_title：Cell metabolism

authors： Greathouse KL,Harris CC,Bultman SJ

更新日期：2015-01-06 00:00:00

abstract：:Defects in insulin secretion play a central role in the pathogenesis of type 2 diabetes, yet the mechanisms driving beta-cell dysfunction remain poorly understood, and therapies to preserve glucose-dependent insulin release are inadequate. We report a luminescent insulin secretion assay that enables large-scale invest...

journal_title：Cell metabolism

authors： Burns SM,Vetere A,Walpita D,Dančík V,Khodier C,Perez J,Clemons PA,Wagner BK,Altshuler D

更新日期：2015-01-06 00:00:00

abstract：:Myriad strategies have been explored to compensate for the lack of dystrophin or to skip mutations that cause the lethal disease Duchenne muscular dystrophy (DMD). A new study shows that gene editing strategies used by bacteria can be applied in zygotes of a mouse model of DMD to correct the genetic defect that causes...

journal_title：Cell metabolism

authors： Tidball JG,Bertoni C

更新日期：2014-12-02 00:00:00

abstract：:Precise control of the thyroid hormone (T3)-dependent transcriptional program is required by multiple cell systems, including muscle stem cells. Deciphering how this is achieved and how the T3 signal is controlled in stem cell niches is essentially unknown. We report that in response to proliferative stimuli such as a...

journal_title：Cell metabolism

authors： Dentice M,Ambrosio R,Damiano V,Sibilio A,Luongo C,Guardiola O,Yennek S,Zordan P,Minchiotti G,Colao A,Marsili A,Brunelli S,Del Vecchio L,Larsen PR,Tajbakhsh S,Salvatore D

更新日期：2014-12-02 00:00:00

abstract：:Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...

journal_title：Cell metabolism

authors： Brown KD,Maqsood S,Huang JY,Pan Y,Harkcom W,Li W,Sauve A,Verdin E,Jaffrey SR

更新日期：2014-12-02 00:00:00

abstract：:Intestinal microbial communities regulate a range of host physiological functions, from energy harvest and glucose homeostasis to immune development and regulation. Suez et al. (2014) recently demonstrated that artificial sweeteners alter gut microbial communities, leading to glucose intolerance in both mice and human...

journal_title：Cell metabolism

authors： Bokulich NA,Blaser MJ

更新日期：2014-11-04 00:00:00

abstract：:Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeosta...

journal_title：Cell metabolism

authors： Walter KM,Schönenberger MJ,Trötzmüller M,Horn M,Elsässer HP,Moser AB,Lucas MS,Schwarz T,Gerber PA,Faust PL,Moch H,Köfeler HC,Krek W,Kovacs WJ

更新日期：2014-11-04 00:00:00

abstract：:Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary c...

journal_title：Cell metabolism

authors： Patterson AD,Turnbaugh PJ

更新日期：2014-11-04 00:00:00

abstract：:The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic ...

journal_title：Cell metabolism

authors： Tung YCL,Yeo GSH,O'Rahilly S,Coll AP

更新日期：2014-11-04 00:00:00

abstract：:Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α-keto acid dehydrogenase (...

journal_title：Cell metabolism

authors： Shin AC,Fasshauer M,Filatova N,Grundell LA,Zielinski E,Zhou JY,Scherer T,Lindtner C,White PJ,Lapworth AL,Ilkayeva O,Knippschild U,Wolf AM,Scheja L,Grove KL,Smith RD,Qian WJ,Lynch CJ,Newgard CB,Buettner C

更新日期：2014-11-04 00:00:00

abstract：:Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) drives expression of genes regulating RCT, and its activity can be ...

journal_title：Cell metabolism

authors： Stein S,Oosterveer MH,Mataki C,Xu P,Lemos V,Havinga R,Dittner C,Ryu D,Menzies KJ,Wang X,Perino A,Houten SM,Melchior F,Schoonjans K

更新日期：2014-10-07 00:00:00

abstract：:The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...

journal_title：Cell metabolism

authors： Owen BM,Ding X,Morgan DA,Coate KC,Bookout AL,Rahmouni K,Kliewer SA,Mangelsdorf DJ

更新日期：2014-10-07 00:00:00

abstract：:Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to the control of bile acid biosynthesis. ...

journal_title：Cell metabolism

authors： Perino A,Schoonjans K

更新日期：2014-08-05 00:00:00

abstract：:Injection of the peptide hormone ghrelin stimulates food intake in mice and humans. However, mice born without ghrelin demonstrate no significant loss of appetite. This paradox suggests either that compensation develops in mice born without ghrelin or that ghrelin is not essential for appetite control. To distinguish ...

journal_title：Cell metabolism

authors： McFarlane MR,Brown MS,Goldstein JL,Zhao TJ

更新日期：2014-07-01 00:00:00

abstract：:Prohibitins form large protein and lipid scaffolds in the inner membrane of mitochondria that are required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. Here, we have defined the interactome of PHB2 in mitochondria and identified DNAJC19, mutated in dilated cardiomyopathy with ataxia, as bin...

journal_title：Cell metabolism

authors： Richter-Dennerlein R,Korwitz A,Haag M,Tatsuta T,Dargazanli S,Baker M,Decker T,Lamkemeyer T,Rugarli EI,Langer T

更新日期：2014-07-01 00:00:00

abstract：:CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...

journal_title：Cell metabolism

authors： Macintyre AN,Gerriets VA,Nichols AG,Michalek RD,Rudolph MC,Deoliveira D,Anderson SM,Abel ED,Chen BJ,Hale LP,Rathmell JC

更新日期：2014-07-01 00:00:00

abstract：:For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuc...

journal_title：Cell metabolism

authors： Yun J,Finkel T

更新日期：2014-05-06 00:00:00

abstract：:Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...

journal_title：Cell metabolism

authors： van Alphen B,Allada R

更新日期：2014-05-06 00:00:00

abstract：:Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...

journal_title：Cell metabolism

authors： Nolan CJ

更新日期：2014-04-01 00:00:00

abstract：:Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram c...

journal_title：Cell metabolism

authors： Thai M,Graham NA,Braas D,Nehil M,Komisopoulou E,Kurdistani SK,McCormick F,Graeber TG,Christofk HR

更新日期：2014-04-01 00:00:00

abstract：:Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autopha...

journal_title：Cell metabolism

authors： Eisenberg T,Schroeder S,Andryushkova A,Pendl T,Küttner V,Bhukel A,Mariño G,Pietrocola F,Harger A,Zimmermann A,Moustafa T,Sprenger A,Jany E,Büttner S,Carmona-Gutierrez D,Ruckenstuhl C,Ring J,Reichelt W,Schimmel K,Lee

更新日期：2014-03-04 00:00:00

abstract：:How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...

journal_title：Cell metabolism

authors： Gao Y,Tschöp MH,Luquet S

更新日期：2014-02-04 00:00:00

abstract：:Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminenc...

journal_title：Cell metabolism

authors： Balland E,Dam J,Langlet F,Caron E,Steculorum S,Messina A,Rasika S,Falluel-Morel A,Anouar Y,Dehouck B,Trinquet E,Jockers R,Bouret SG,Prévot V

更新日期：2014-02-04 00:00:00

abstract：:Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized, primarily due to lack of robust analytical techniques. Using comparative metabolom...

journal_title：Cell metabolism

authors： Mahanti P,Bose N,Bethke A,Judkins JC,Wollam J,Dumas KJ,Zimmerman AM,Campbell SL,Hu PJ,Antebi A,Schroeder FC

更新日期：2014-01-07 00:00:00

abstract：:Accumulating evidence suggests that changes in the metabolic signature of astrocytes underlie their response to neuroinflammation, but how proinflammatory stimuli induce these changes is poorly understood. By monitoring astrocytes following acute cortical injury, we identified a differential and region-specific remode...

journal_title：Cell metabolism

authors： Motori E,Puyal J,Toni N,Ghanem A,Angeloni C,Malaguti M,Cantelli-Forti G,Berninger B,Conzelmann KK,Götz M,Winklhofer KF,Hrelia S,Bergami M

更新日期：2013-12-03 00:00:00

abstract：:Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We sho...

journal_title：Cell metabolism

authors： Masui K,Tanaka K,Akhavan D,Babic I,Gini B,Matsutani T,Iwanami A,Liu F,Villa GR,Gu Y,Campos C,Zhu S,Yang H,Yong WH,Cloughesy TF,Mellinghoff IK,Cavenee WK,Shaw RJ,Mischel PS

更新日期：2013-11-05 00:00:00

abstract：:Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FND...

journal_title：Cell metabolism

authors： Xu B

更新日期：2013-11-05 00:00:00

abstract：:Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descend...

journal_title：Cell metabolism

authors： Greer EL,Shi Y

更新日期：2013-10-01 00:00:00

abstract：:Most mitochondrial proteins are imported by the translocase of the outer mitochondrial membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the import pore. Casein kinase 2 (CK2) constitutively phosphorylates the cytosolic precursor of Tom22 at Ser44 and Ser46 and, thus, promotes its import...

journal_title：Cell metabolism

authors： Gerbeth C,Schmidt O,Rao S,Harbauer AB,Mikropoulou D,Opalińska M,Guiard B,Pfanner N,Meisinger C

更新日期：2013-10-01 00:00:00

abstract：:Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an e...

journal_title：Cell metabolism

authors： Sun K,Tordjman J,Clément K,Scherer PE

更新日期：2013-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demon...

journal_title：Cell metabolism

authors： el Azzouzi H,Leptidis S,Dirkx E,Hoeks J,van Bree B,Brand K,McClellan EA,Poels E,Sluimer JC,van den Hoogenhof MM,Armand AS,Yin X,Langley S,Bourajjaj M,Olieslagers S,Krishnan J,Vooijs M,Kurihara H,Stubbs A,Pinto YM,

更新日期：2013-09-03 00:00:00

abstract：:In this issue of Cell Metabolism, Mounier et al. (2013) show that AMPKα1 is a crucial contributor to the regeneration of damaged muscle tissues, acting in macrophages at the nexus between proinflammatory debris removal and resolution of muscle tissue inflammation. ...

journal_title：Cell metabolism

authors： Krishnan V,Yaden BC

更新日期：2013-08-06 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and me...

journal_title：Cell metabolism

authors： Ahrens M,Ammerpohl O,von Schönfels W,Kolarova J,Bens S,Itzel T,Teufel A,Herrmann A,Brosch M,Hinrichsen H,Erhart W,Egberts J,Sipos B,Schreiber S,Häsler R,Stickel F,Becker T,Krawczak M,Röcken C,Siebert R,Schafmayer

更新日期：2013-08-06 00:00:00

abstract：:Oxidants are thought to damage cells, and stem cells are viewed as particularly vulnerable to oxidative stress. Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS). ...

journal_title：Cell metabolism

authors： Liu J,Finkel T

更新日期：2013-07-02 00:00:00

abstract：:Insulin rapidly suppresses hepatic glucose production and slowly decreases expression of genes encoding gluconeogenic proteins. In this study, we show that an immediate effect of insulin is to redirect newly synthesized glucose-6-phosphate to glycogen without changing the rate of gluconeogenesis. This process requires...

journal_title：Cell metabolism

authors： Wan M,Leavens KF,Hunter RW,Koren S,von Wilamowitz-Moellendorff A,Lu M,Satapati S,Chu Q,Sakamoto K,Burgess SC,Birnbaum MJ

更新日期：2013-07-02 00:00:00

abstract：:Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, re...

journal_title：Cell metabolism

authors： Mirisola MG,Longo VD

更新日期：2013-06-04 00:00:00

abstract：:The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces Grb14 in pancreatic en...

journal_title：Cell metabolism

authors： Ezzat S,Zheng L,Florez JC,Stefan N,Mayr T,Hliang MM,Jablonski K,Harden M,Stančáková A,Laakso M,Haring HU,Ullrich A,Asa SL

更新日期：2013-06-04 00:00:00